Research Article
Solar-Assisted Green Synthesis, Molecular Docking, Antibacterial, and Cytotoxicity Studies of Symmetrical N, N’-Alkylidene Bisamides Bearing Lower E-Factors
Omkar Sharad Kamble,
Rana Chatterjee,
Shubhada Gad,
Samarth Kansara,
Sonal Ayakar,
Amit Kumar Pandey,
Rambabu Dandela*
Issue:
Volume 10, Issue 1, June 2024
Pages:
1-12
Received:
27 January 2024
Accepted:
18 February 2024
Published:
13 March 2024
DOI:
10.11648/j.ajhc.20241001.11
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Abstract: N, N'-alkylidene bisamides show promise in biological and pharmaceutical uses. Advanced chemistry now explores cleaner and more environmentally friendly methods. One such method involves using concentrated solar radiation (CSR) to facilitate the green synthesis of N, N'-alkylidene bisamides. This approach simplifies the process by combining aldehydes and amides in a one-pot reaction. Its solvent-free nature sets it apart, aligning with environmentally friendly practices. Any regular catalyst aids the response, making it efficient. The simplicity continues with an easy filtration step to isolate the products. Notably, there's no need for column chromatography, making the purification process straightforward. In general, a mixture of aldehyde, aryl/alkylamide was taken in a round bottom flask. The reaction mass in RBF was then kept under the concentrated solar radiation (CSR) setup with continuous stirring on a magnetic stirrer. After few hours of stirring the precipitate was observed. After completion of the reaction, the precipitated product was washed with water and recrystallized from hot ethanol to afford pure product symmetrical N, N'-alkylidene bisamide. Dimethyl sulfoxide (DMSO) was used as a solvent to prepare a stock of derivatives. Luria Bertani broth (LB) used for the present study viz; Staphylococ-cus aureus MCC 2408, Escherichia coli MCC 2412, Pseudomonas aeruginosa MCC 2080 and Klebsiella pneumoniae MCC 2451 used to evaluate the antibacterial property of the derivatives. Indeed, this method offers an eco-friendly solution and showcases the potential of using renewable energy sources in chemical synthesis. It is a significant step towards sustainable practices in chemistry, particularly in producing complex organic compounds for biological and pharmaceutical purposes.
Abstract: N, N'-alkylidene bisamides show promise in biological and pharmaceutical uses. Advanced chemistry now explores cleaner and more environmentally friendly methods. One such method involves using concentrated solar radiation (CSR) to facilitate the green synthesis of N, N'-alkylidene bisamides. This approach simplifies the process by combining aldehyd...
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Research Article
Excess Molar Volume and Deviations in Viscosity of the Binary Liquid Mixtures Containing 1,3-Dioxolane + Alkanols at T = 298.15k
Issue:
Volume 10, Issue 1, June 2024
Pages:
13-25
Received:
21 August 2024
Accepted:
18 September 2024
Published:
29 September 2024
DOI:
10.11648/j.ajhc.20241001.12
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Abstract: Thermodynamic and transport properties of liquid and liquid mixtures have been used to understand the intermolecular interactions between the components of the mixture. The sound velocity, density and viscosity of binary liquid mixtures are important from practical and theoretical point of view to understand the liquid theory. In the present study sound velocity, density and viscosity have been measured of binary mixtures of 1, 3-dioxolane with pentanol, hexanol, heptanol, octanol, nonanol and decanol over the entire range of mole fraction at 298.15K, and atmospheric pressure. From these experimental measurements the excess molar volume (VmE), excess viscosity (ηE), acoustic impedance (ZE) and excess adiabatic compressibility (βadE), have been calculated. The excess molar volume (VmE), excess viscosity (ηE), acoustic impedance (ZE) and excess adiabatic compressibility (βadE), have been analyzed in terms of interactions arising due to structural effect, charge-transfer complexes and dipole-dipole interaction between unlike molecules. These deviations have been correlated by a polynomial Redlich-Kister equation. The excess properties are found to be eighter negative or positive depending on the molecular interactions and nature of the liquid mixtures. Excess properties provide important information in understanding the solute-solvent interaction in a solution. The excess molar volume (VmE), excess viscosity (ηE), acoustic impedance (ZE) and excess adiabatic compressibility (βadE), values have been interpreted to terms of the nature of intermolecular interactions between constituent molecules of mixtures.
Abstract: Thermodynamic and transport properties of liquid and liquid mixtures have been used to understand the intermolecular interactions between the components of the mixture. The sound velocity, density and viscosity of binary liquid mixtures are important from practical and theoretical point of view to understand the liquid theory. In the present study ...
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,
Dhirendra Kumar Sharma*
