Volume 6, Issue 1, June 2020, Page: 1-5
Green Protocol for the Synthesis of Catalyst Free Biginelli Products
Abdul Ghafoor, Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Naved Sajid, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Muhammad Adnan, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Muhammad Naeem Khan, Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Amin Abid, Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Ansa Madeeha Zafar, Department of Chemistry, The Women University, Bahawalpur, Pakistan
Muhammad Ahmad, Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Noreen Aslam, Department of Chemistry, The Women University, Bahawalpur, Pakistan
Mussarat Jabeen, Department of Chemistry, The Women University, Bahawalpur, Pakistan
Amjad Ali, Department of Anatomy, CMH Institute of Medical Sciences, Multan, Pakistan
Misbahul Ain Khan, Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Received: Sep. 5, 2019;       Accepted: Apr. 26, 2020;       Published: May 28, 2020
DOI: 10.11648/j.ajhc.20200601.11      View  120      Downloads  50
Abstract
Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (­thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.
Keywords
Green Chemistry, 3, 4-Dihydropyrimidones, 3, 4-Dihydropyrimidothiones, Multi Component, Synthetic Methods, One pot, Catalyst Free Reactions
To cite this article
Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, Ansa Madeeha Zafar, Muhammad Ahmad, Noreen Aslam, Mussarat Jabeen, Amjad Ali, Misbahul Ain Khan, Green Protocol for the Synthesis of Catalyst Free Biginelli Products, American Journal of Heterocyclic Chemistry. Vol. 6, No. 1, 2020, pp. 1-5. doi: 10.11648/j.ajhc.20200601.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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