Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins:: Science Publishing Group

Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins

Youssoufou Bakouan¹, Bintou Sessouma¹, Têeda Hamidou Ganamé², Lassané Tarpaga¹, Jules Yoda³, Karifa Bayo¹

¹Laboratory of Molecular and Materials Chemistry (LC2M), University Joseph Ki-ZERBO, Ouagadougou, Burkina Faso

²Laboratory of Analytical, Environmental and Bioorganic chemistry (LCAEBiO), University Joseph KI-ZERBO, Ouagadougou, Burkina Faso

³Department of Traditional Medicine and Pharmacopoeia-Pharmacy (MEPHATRA-Ph), Research Institute for Health Sciences (IRSS), Ouagadougou, Burkina Faso

American Journal of Heterocyclic Chemistry, Volume 7, Issue 2, December 2021

Pages: 33-38

Received: Nov. 08, 2021

Accepted: Dec. 02, 2021

Published: Dec. 07, 2021

DOI: 10.11648/j.ajhc.20210702.13

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Abstract

Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.

Keywords

4-hydroxycoumarins, C-acylation, Acyl-hydroxycoumarins, Heterocyclic Compound

To cite this article

Youssoufou Bakouan, Bintou Sessouma, Têeda Hamidou Ganamé, Lassané Tarpaga, Jules Yoda, et al. (2021). Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. American Journal of Heterocyclic Chemistry, 7(2), 33-38. https://doi.org/10.11648/j.ajhc.20210702.13

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This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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