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Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins

Received: 8 November 2021     Accepted: 2 December 2021     Published: 7 December 2021
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Abstract

Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.

Published in American Journal of Heterocyclic Chemistry (Volume 7, Issue 2)
DOI 10.11648/j.ajhc.20210702.13
Page(s) 33-38
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

4-hydroxycoumarins, C-acylation, Acyl-hydroxycoumarins, Heterocyclic Compound

References
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    Youssoufou Bakouan, Bintou Sessouma, Têeda Hamidou Ganamé, Lassané Tarpaga, Jules Yoda, et al. (2021). Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. American Journal of Heterocyclic Chemistry, 7(2), 33-38. https://doi.org/10.11648/j.ajhc.20210702.13

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    ACS Style

    Youssoufou Bakouan; Bintou Sessouma; Têeda Hamidou Ganamé; Lassané Tarpaga; Jules Yoda, et al. Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. Am. J. Heterocycl. Chem. 2021, 7(2), 33-38. doi: 10.11648/j.ajhc.20210702.13

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    AMA Style

    Youssoufou Bakouan, Bintou Sessouma, Têeda Hamidou Ganamé, Lassané Tarpaga, Jules Yoda, et al. Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins. Am J Heterocycl Chem. 2021;7(2):33-38. doi: 10.11648/j.ajhc.20210702.13

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  • @article{10.11648/j.ajhc.20210702.13,
      author = {Youssoufou Bakouan and Bintou Sessouma and Têeda Hamidou Ganamé and Lassané Tarpaga and Jules Yoda and Karifa Bayo},
      title = {Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins},
      journal = {American Journal of Heterocyclic Chemistry},
      volume = {7},
      number = {2},
      pages = {33-38},
      doi = {10.11648/j.ajhc.20210702.13},
      url = {https://doi.org/10.11648/j.ajhc.20210702.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20210702.13},
      abstract = {Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Some Aspects of the Reactivity of 3-acyl-4-hydroxycoumarins
    AU  - Youssoufou Bakouan
    AU  - Bintou Sessouma
    AU  - Têeda Hamidou Ganamé
    AU  - Lassané Tarpaga
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    Y1  - 2021/12/07
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    N1  - https://doi.org/10.11648/j.ajhc.20210702.13
    DO  - 10.11648/j.ajhc.20210702.13
    T2  - American Journal of Heterocyclic Chemistry
    JF  - American Journal of Heterocyclic Chemistry
    JO  - American Journal of Heterocyclic Chemistry
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    EP  - 38
    PB  - Science Publishing Group
    SN  - 2575-5722
    UR  - https://doi.org/10.11648/j.ajhc.20210702.13
    AB  - Coumarins are the most important oxygenated heterocyclic of natural compounds. They are widely used as raw materials in many areas such as agrochemical, perfume, pharmaceutical industries. They therefore have several physical, chemical and biological properties. In order to enlarge this family of compounds and elucidate almost all of its properties, researchers have developed various synthetic methods that are not very complex and less expensive. Thus, from 4-hydroxycoumarin we have synthesized a series of 3-acyl-4-hydroxycoumarins by C-acylation. This study is therefore dedicated to the reactivity of 3-acyl-4-hydroxycoumarins. The synthesized coumarins showed a high reaction potential based on the chemical functions present in their structures. To enhance them later, we can try to graft other functions which can be the subject of several transformations such as: condensation, functionalization, cyclization, acylation. So to access more interesting new poly-functionalized compounds both at the reactivity and biological level. These molecules (3-acyl-4-hydroxycoumarins) being new, very little information is known on their physicochemical behavior in writings. On the other hand, the reactivity of molecules with similar structures to those of acyl-hydroxycoumarins such as 4-acylisochroman-1,3-diones and 3-acetyl-4-hydroxycoumarin have been the subject of scientists’ work. It emerges from this study that 3-acyl-4-hydroxycoumarins shows strong chemical reactivity which can be used biologically.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Laboratory of Molecular and Materials Chemistry (LC2M), University Joseph Ki-ZERBO, Ouagadougou, Burkina Faso

  • Laboratory of Molecular and Materials Chemistry (LC2M), University Joseph Ki-ZERBO, Ouagadougou, Burkina Faso

  • Laboratory of Analytical, Environmental and Bioorganic chemistry (LCAEBiO), University Joseph KI-ZERBO, Ouagadougou, Burkina Faso

  • Laboratory of Molecular and Materials Chemistry (LC2M), University Joseph Ki-ZERBO, Ouagadougou, Burkina Faso

  • Department of Traditional Medicine and Pharmacopoeia-Pharmacy (MEPHATRA-Ph), Research Institute for Health Sciences (IRSS), Ouagadougou, Burkina Faso

  • Laboratory of Molecular and Materials Chemistry (LC2M), University Joseph Ki-ZERBO, Ouagadougou, Burkina Faso

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