American Journal of Heterocyclic Chemistry

Volume 2, Issue 1, December 2016

  • A Study of the Kinetic and Mechanism of Oxidation of Pyrazole Derivative by Permanganate Ion in Neutral Medium and the Effect of Metal Ion Catalysts

    Ismail Althagafi, Ahmed Fawzy

    Issue: Volume 2, Issue 1, December 2016
    Pages: 1-7
    Received: Sep. 16, 2016
    Accepted: Oct. 31, 2016
    Published: Nov. 21, 2016
    DOI: 10.11648/j.ajhc.20160201.11
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    Abstract: Oxidation of methylaminopyrazole formamidine (MAPF) by permanganate ion was studied spectrophotometrically in neutral medium in the presence of phosphate buffer solution. The stoichiometry of the reaction was found to be 3: 2 (MAPF: MnO 4-). The oxidation reaction showed a first order kinetics with respect to [MnO4-] and a fractional-first order de... Show More
  • Spectroscopic Identification and Synthesis of Derivatives of Pyrimidine 2- Thione Via Two Different Spacers

    Moayed J. Mohammed, Ahmed Kh. Ahmed, Faris T. Abachi

    Issue: Volume 2, Issue 1, December 2016
    Pages: 8-12
    Received: Oct. 28, 2016
    Accepted: Nov. 12, 2016
    Published: Dec. 10, 2016
    DOI: 10.11648/j.ajhc.20160201.12
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    Abstract: A new series of pyrimidine -2-thione derivatives were synthesized via two routes and designated as antifolate. The heterocyclic ring was prepared by direct reaction of benzoyl acetone with thiosemicarbiazide in acidic medium. Also, the pyrimidine-2-thione ring reacts with p-aminobenzoic acid to form 4-amino-N-(4-methyl-6-phenyl)-2-thioxypyrimidine ... Show More
  • Aqueous Synthesis and Biological Studies of Indole Derivatives

    Sudhakara Aralihalli, Raghavendra Ramappa, Harish Basavanthappa Gowdru, Nataraja Gummanar, Ramesha Sonnappa, Mahadevan Kittappa Malavalli

    Issue: Volume 2, Issue 1, December 2016
    Pages: 13-19
    Received: Oct. 26, 2016
    Accepted: Nov. 12, 2016
    Published: Dec. 27, 2016
    DOI: 10.11648/j.ajhc.20160201.13
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    Abstract: One pot with expedient approach to the synthesis of 2,3-disubstituted indole derivatives using indium (III) trichloride through Fisher indole method has been developed, in aqueous media. The synthesized compounds were screened for their anti analgesic and antibacterial activity. All the six indole derivatives exhibited significant antibacterial act... Show More
  • Aqueous Polyurethane Dispersions - Sodium Alginate Based Blends and Hydrogels

    Tamara Travinskaya, Yuri Savelyev

    Issue: Volume 2, Issue 1, December 2016
    Pages: 20-25
    Received: Oct. 28, 2016
    Accepted: Nov. 24, 2016
    Published: Jan. 05, 2017
    DOI: 10.11648/j.ajhc.20160201.14
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    Abstract: The film forming binary polyurethane-alginate blends and based hydrogels, containing different alginate content, were prepared by blending of anionic polyurethane dispersions (APD) and aqueous sodium alginate (SA) solution. Binary blends of APD and SA were cast in film form from mixed aqueous polymer solutions by solvent evaporation. Post-treatment... Show More
  • Synthesis and Characterization of New Complex Heterocyclic Ring Systems of Industrial Importance

    Ayuk Eugene Lakem, Nweke Cletus Mgadiugha, Ugwu Marigoretti Ogechukwu

    Issue: Volume 2, Issue 1, December 2016
    Pages: 26-31
    Received: Jul. 12, 2016
    Accepted: Dec. 19, 2016
    Published: Jan. 10, 2017
    DOI: 10.11648/j.ajhc.20160201.15
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    Abstract: The synthesis and characterization of new complex monoaza and pentaaza angular phenothiazine derivatives is reported. The first derivative, 6,10-dichloro-17-azadibenzo[a,n]triphenodithiazin-5,11-dione 10 was obtained by a base-catalyzed reaction of 2,6-diaminopyridine-3,5-dithiol 5 and 2,3-dichloro-1,4-naphthaquinone 9, while the second derivative,... Show More
  • Synthesis of Some New N-[1-(Benzocoumarin-3`-yl)Ethylidene]Hydrazonothiazolidine, Thiazole and 1, 3, 4-Thidiazole Derivatives

    Hussein A. Emam, Saber M. Hassan, Ahmed M. El-Agrody, Ahmed H. Bedair, Mahmoud M. Abdelall

    Issue: Volume 2, Issue 1, December 2016
    Pages: 32-38
    Received: Dec. 10, 2016
    Accepted: Dec. 22, 2016
    Published: Jan. 12, 2017
    DOI: 10.11648/j.ajhc.20160201.16
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    Abstract: Condensation of 3-acetylbenzo[5,6]coumarin (1) with hydrazine-carbodithioate esters and/or thiocarbohydrazide gave the corresponding N-[1-(benzocoumarin-3`-yl)ethylidene]hydrazonecarbodithioate (2a,b) and 1,5-bis[1-(benzocoumarin-3`-yl)ethylidene]thiocarbohydrazide (3) respectively. Treatment of 2a with ethanolic ammonia solution and/or amines gave... Show More