American Journal of Heterocyclic Chemistry

Volume 3, Issue 1, February 2017

  • Synthesis and Antimicrobial Activities Evaluation of New Spiro[4.5]dec-2-enes Containing 1,2,4-Triazole, Piperidine and Sulfonamide Moieties

    Hany Mahmoud Dalloul, Khaled A. El-nwairy, Ali Zayed Shorafa, Ahmed Sulyman Abu Samaha

    Issue: Volume 3, Issue 1, February 2017
    Pages: 1-7
    Received: Oct. 28, 2016
    Accepted: Feb. 10, 2017
    Published: Mar. 01, 2017
    Abstract: A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthes... Show More